Search results for "human intestinal enteroids"

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Human Intestinal Enteroids to Evaluate Human Norovirus GII.4 Inactivation by Aged-Green Tea

2020

Human noroviruses are the leading cause of epidemic and sporadic acute gastroenteritis worldwide and the most common cause of foodborne illness in the United States. Several natural compounds, such as aged-green tea extract (aged-GTE), have been suggested as ingestible antiviral agents against human norovirus based on data using murine norovirus and feline calicivirus as surrogates. However, in vitro data showing their effectiveness against infectious human norovirus are lacking. We tested the activity of aged-GTE to inhibit human norovirus in a human intestinal enteroids (HIEs) model and Tulane virus in LLC-monkey kidney (LLC-MK2) cell culture. HIE monolayers pretreated with aged-GTE at di…

Microbiology (medical)human norovirusvirusesved/biology.organism_classification_rank.specieslcsh:QR1-502medicine.disease_causeMicrobiologylcsh:Microbiologynatural compound03 medical and health sciencesfluids and secretionsmedicineTulane virusTulane virusOriginal Research030304 developmental biologyInfectivity0303 health sciencesFeline calicivirusKidneybiology030306 microbiologyved/biologyvirus diseasesbiology.organism_classificationVirologyIn vitromedicine.anatomical_structureCell cultureaged-green teaNorovirushuman intestinal enteroidsMurine norovirusFrontiers in Microbiology

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